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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG1 All Species: 18.18
Human Site: S612 Identified Species: 36.36
UniProt: P19174 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P19174 NP_002651.2 1290 148532 S612 V Q H C R I H S R Q D A G T P
Chimpanzee Pan troglodytes XP_514650 1630 185027 S952 V Q H C R I H S R Q D A G T P
Rhesus Macaque Macaca mulatta XP_001087295 1291 148567 S612 V Q H C R I H S R Q D A G T P
Dog Lupus familis XP_542998 1249 143812 F581 Q D A G A P K F F L T D N L V
Cat Felis silvestris
Mouse Mus musculus Q62077 1302 149650 S612 V Q H C R I H S R Q D A G T P
Rat Rattus norvegicus P10686 1290 148530 S612 V Q H C R I H S R Q D A G T P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q2VRL0 637 72514 L28 D F D S T V K L L E K L H M P
Frog Xenopus laevis Q32NH8 758 87399 N149 W F Q K A D K N K D G R M N F
Zebra Danio Brachydanio rerio A5D6R3 784 89362 Q175 L R R A D Q N Q D G K M S Y D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13217 1095 124845 G486 E L E L W L K G E L K T D D D
Honey Bee Apis mellifera XP_624101 1134 132613 K525 Y C L S F W R K G K V N H C R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 R331 E D M L K R V R Q D G A F L V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79 99.5 93.2 N.A. 95.3 96.9 N.A. N.A. 21.4 21.7 21.8 N.A. 21.4 45.1 N.A. 35.1
Protein Similarity: 100 79 99.7 94.5 N.A. 96.7 98.2 N.A. N.A. 32.4 37.3 36.3 N.A. 40 62 N.A. 50
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. N.A. 6.6 0 0 N.A. 0 0 N.A. 6.6
P-Site Similarity: 100 100 100 0 N.A. 100 100 N.A. N.A. 20 13.3 20 N.A. 6.6 6.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 9 17 0 0 0 0 0 0 50 0 0 0 % A
% Cys: 0 9 0 42 0 0 0 0 0 0 0 0 0 9 0 % C
% Asp: 9 17 9 0 9 9 0 0 9 17 42 9 9 9 17 % D
% Glu: 17 0 9 0 0 0 0 0 9 9 0 0 0 0 0 % E
% Phe: 0 17 0 0 9 0 0 9 9 0 0 0 9 0 9 % F
% Gly: 0 0 0 9 0 0 0 9 9 9 17 0 42 0 0 % G
% His: 0 0 42 0 0 0 42 0 0 0 0 0 17 0 0 % H
% Ile: 0 0 0 0 0 42 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 9 9 0 34 9 9 9 25 0 0 0 0 % K
% Leu: 9 9 9 17 0 9 0 9 9 17 0 9 0 17 0 % L
% Met: 0 0 9 0 0 0 0 0 0 0 0 9 9 9 0 % M
% Asn: 0 0 0 0 0 0 9 9 0 0 0 9 9 9 0 % N
% Pro: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 50 % P
% Gln: 9 42 9 0 0 9 0 9 9 42 0 0 0 0 0 % Q
% Arg: 0 9 9 0 42 9 9 9 42 0 0 9 0 0 9 % R
% Ser: 0 0 0 17 0 0 0 42 0 0 0 0 9 0 0 % S
% Thr: 0 0 0 0 9 0 0 0 0 0 9 9 0 42 0 % T
% Val: 42 0 0 0 0 9 9 0 0 0 9 0 0 0 17 % V
% Trp: 9 0 0 0 9 9 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _